Observation of Ultrafast Vibrational Energy Transfer in Fibrinogen and Fibrin Fibers
J. Phys. Chem. B , Volume 122 - Issue 22 p. 5870- 5876
We study the secondary structure of the blood protein fibrinogen using two-dimensional infrared spectroscopy. With this technique, we identify the amide I′ vibrational modes of the antiparallel β-sheets and turns of fibrinogen. We observe ultrafast energy flow among these amide I′ vibrational modes with a time constant of ∼7 ps. This energy transfer time constant does not change significantly upon fibrin fiber formation, indicating that the secondary structure of the fibrinogen monomers remains largely unchanged in the polymerization process.
|J. Phys. Chem. B|
Dutta, B, Vos, B.E, Koenderink, G.H, & Bakker, H.J. (2018). Observation of Ultrafast Vibrational Energy Transfer in Fibrinogen and Fibrin Fibers. J. Phys. Chem. B, 122(22), 5870–5876. doi:10.1021/acs.jpcb.8b03490