2018-08-24
The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids
Publication
Publication
Chem. Commun. , Volume 54 p. 10832- 10834
The Strecker reaction is broadly used for the preparation of α-amino acids. However, control of enantioselectivity remains challenging. We here couple the Strecker reaction to Viedma ripening for the absolute asymmetric synthesis of highly sterically hindered α-amino acids. As proof-of-principle, the enantiomerically pure α-amino acids tert-leucine and α-(1-adamantyl)glycine were obtained.
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| RSC | |
| doi.org/10.1039/C8CC06658B | |
| Chem. Commun. | |
| Organisation | Self-Organizing Matter |
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Baglai, I., Leeman, M., Wurst, K., Kaptein, B., Kellogg, R., & Noorduin, W. (2018). The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids. Chem. Commun., 54, 10832–10834. doi:10.1039/C8CC06658B |
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