A simple asymmetric synthesis route to the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

Org. Biomol. Chem
Self-Organizing Matter

Baglai, I., Leeman, M., Kellogg, R., & Noorduin, W. (2019). A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam. Org. Biomol. Chem, 17(1), 35–38. doi:10.1039/C8OB02660B