A simple asymmetric synthesis route to the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

Additional Metadata
Publisher RSC
Persistent URL dx.doi.org/10.1039/C8OB02660B
Journal Org. Biomol. Chem
Citation
Baglai, I, Leeman, M, Kellogg, R.M, & Noorduin, W.L. (2019). A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam. Org. Biomol. Chem, 17(1), 35–38. doi:10.1039/C8OB02660B