Herein we introduce a “chiral switch” – a sequence of operations that alternate between equilibrium and non-equilibrium conditions to switch the absolute configuration of a chiral center. The generality and practical potential of the technique are demonstrated with three unnatural α-amino acid precursors.

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doi.org/10.1039/c9cc03250a
Chem. Commun.
Self-Organizing Matter

Baglai, I, Leeman, M, Kaptein, B, Kellogg, R.M, & Noorduin, W.L. (2019). A chiral switch: balancing between equilibrium and non-equilibrium states. Chem. Commun., 55(48), 6910–6913. doi:10.1039/c9cc03250a