Impact of crowders on the morphology of bacterial chromosomes
Inspired by recent experiments on the effects of cytosolic crowders on the organization of bacterial chromosomes, we consider a "feather-boa" type model chromosome in the presence of non-additive crowders, encapsulated within a cylindrical cell. We observe spontaneous emergence of complementary helicity of the confined polymer and crowders. This feature is reproduced within a simplified effective model of the chromosome. This latter model further establishes the occurrence of longitudinal and transverse spatial segregation transitions between the chromosome and crowders upon increasing the crowder size.
|Keywords||General Physics and Astronomy|
Kumar, A, Swain, P, Mulder, B.M, & Chaudhuri, D. (2020). Impact of crowders on the morphology of bacterial chromosomes. EPL, 128(6), 68003: 1–68003: 7. doi:10.1209/0295-5075/128/68003