Inspired by recent experiments on the effects of cytosolic crowders on the organization of bacterial chromosomes, we consider a "feather-boa" type model chromosome in the presence of non-additive crowders, encapsulated within a cylindrical cell. We observe spontaneous emergence of complementary helicity of the confined polymer and crowders. This feature is reproduced within a simplified effective model of the chromosome. This latter model further establishes the occurrence of longitudinal and transverse spatial segregation transitions between the chromosome and crowders upon increasing the crowder size.

General Physics and Astronomy
Theory of Biomolecular Matter

Kumar, A, Swain, P, Mulder, B.M, & Chaudhuri, D. (2020). Impact of crowders on the morphology of bacterial chromosomes. EPL, 128(6), 68003: 1–68003: 7. doi:10.1209/0295-5075/128/68003