Combining incompatible processes for deracemization of a Praziquantel derivative under flow conditions
Angew. Chem., Int. Ed. , Volume 60 - Issue 10 p. 5279- 5282
An efficient deracemization method for conversion of the racemate to the desirable ( R )‐enantiomer has been developed by coupling incompatible racemization and crystallization processes. By a library approach a derivative that crystallizes as a conglomerate in the solid phase has been identified. Racemization occurs via reversible hydrogenation over a palladium on carbon (Pd/C) packed column at 130 °C, whereas deracemization is achieved by alternating crystal growth/dissolution steps with temperature cycling between 5‐15 °C. These incompatible processes are combined by means of a flow system. Complete deracemization of the solid phase to the desired ( R )‐enantiomer (98% ee) takes place. Such an unprecedented deracemization by a decoupled crystallization/racemization approach can readily be turned into a practical process, and opens new opportunities for the development of essential enantiomerically pure building blocks that require harsh methods for racemization.
|European Union Horizon 2020|
|Angew. Chem., Int. Ed.|
Valenti, G, Tinnemans, P, Baglai, I, Noorduin, W.L, Kaptein, B, Leeman, M, … Kellogg, R.M. (2021). Combining incompatible processes for deracemization of a Praziquantel derivative under flow conditions. Angew. Chem., Int. Ed., 60(10), 5279–5282. doi:10.1002/ange.202013502