We demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition. We establish that the combination of slow growth and fast dissolution of crystals is ideal for rapid deracemization, which we achieve by repurposing a Soxhlet apparatus to realize the slow removal and fast re-addition of solvent autonomously.

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The Netherlands Organisation for Scientific Research (NWO)
Chem. Commun.
Self-Organizing Matter

van Dongen, S., Baglai, I., Leeman, M., Kellogg, R., Kaptein, B., & Noorduin, W. (2023). Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor. Chem. Commun., 59(26), 3838–3841. doi:10.1039/d3cc00332a