2023-02-20
Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor
Publication
Publication
Chem. Commun. , Volume 59 - Issue 26 p. 3838- 3841
We demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition. We establish that the combination of slow growth and fast dissolution of crystals is ideal for rapid deracemization, which we achieve by repurposing a Soxhlet apparatus to realize the slow removal and fast re-addition of solvent autonomously.
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| , , , , , , , , | |
| RSC | |
| The Netherlands Organisation for Scientific Research (NWO) | |
| doi.org/10.1039/d3cc00332a | |
| Chem. Commun. | |
| Organisation | Self-Organizing Matter |
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van Dongen, S., Baglai, I., Leeman, M., Kellogg, R., Kaptein, B., & Noorduin, W. (2023). Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor. Chem. Commun., 59(26), 3838–3841. doi:10.1039/d3cc00332a |
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