2025-10-27
Deracemization by coupling electrochemically assisted racemization and asymmetric crystallization
Publication
Publication
Chem. Commun. , Volume 61 - Issue 95 p. 18834- 18837
Amino acid derivatives of tert-leucine and phenyl glycine along with plant growth retardant and the precursor of fungicide paclobutrazol are deracemized by combining in situ electrochemical base generation to induce racemization and crystallization-induced chiral amplification in a one-pot, two-step deracemization procedure. Full enantioselective conversion (e.e. > 99%) of a mixture of enantiomers towards the desired handedness is achieved.
| Additional Metadata | |
|---|---|
| RSC | |
| Netherlands Organisation for Scientific Research (NWO) , European Union Research and Innovation Horizon 2020 | |
| doi.org/10.1039/d5cc05874k | |
| Chem. Commun. | |
| Organisation | Self-Organizing Matter |
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Léonard, A.-S., Regnier, M., Bertuletti, S., van Dongen, S., Listro, R., Leeman, M., … Noorduin, W. (2025). Deracemization by coupling electrochemically assisted racemization and asymmetric crystallization. Chem. Commun., 61(95), 18834–18837. doi:10.1039/d5cc05874k |
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