We report molecular dynamics simulations of the segregation of two overlapping chains in cylindrical confinement. We find that the entropic repulsion between chains can be sufficiently strong to cause segregation on a time scale that is short compared to the one for diffusion. This result implies that entropic driving forces are sufficiently strong to cause rapid bacterial chromosome segregation.

dx.doi.org/10.1103/physreve.76.031901
Phys. Rev. E

Arnold, A, & Jun, S. (2007). Time scale of entropic segregation of flexible polymers in confinement: implications for chromosome segregation in filamentous bacteria. Phys. Rev. E, 76(3, Article number: 31901), 1–5. doi:10.1103/physreve.76.031901