Probing the structure of a rotaxane with two-dimensional infrared spectroscopy
Femtosecond 2D-IR spectroscopy has been used to study the structure of a rotaxane composed of a benzylic amide macrocycle that is mechanically interlocked onto a succinamide-based thread. Both the macrocycle and the thread contain carbonyl groups, and by determining the coupling between the stretching modes of these groups from the cross-peaks in the 2D-IR spectrum, the structure of the macrocycle-thread system has been probed. Our results demonstrate that 2D-IR spectroscopy can be used to observe structural changes in molecular devices on a picosecond time scale.
Larsen, O.F.A, Bodis, P, Buma, W.J, Hannam, J.S, Leigh, D.A, & Woutersen, S. (2005). Probing the structure of a rotaxane with two-dimensional infrared spectroscopy. PNAS, 102, 13378–13382. doi:10.1073/pnas.0505313102