Detection Systems For Mass Spectrometry Imaging - A Perspective on Novel Developments with a Focus on Active Pixel Detectors
Instrumental developments for imaging and individual particle detection for biomolecular mass spectrometry (imaging) and fundamental atomic and molecular physics studies are reviewed. Ion-counting detectors, array detection systems and high mass detectors for mass spectrometry (imaging) are treated. State-of-the-art detection systems for multi-dimensional ion, electron and photon detection are highlighted. Their application and performance in three different imaging modes - integrated, selected and spectral image detection - are described. Electro-optical and microchannel-plate-based systems are contrasted. The analytical capabilities of solid-state pixel detectors - both charge coupled device (CCD) and complementary metal oxide semiconductor (CMOS) chips - are introduced. The Medipix/Timepix detector family is described as an example of a CMOS hybrid active pixel sensor. Alternative imaging methods for particle detection and their potential for future applications are investigated.
|Journal||Rapid Commun. Mass Spectrom.|
Jungmann, J.H, & Heeren, R.M.A. (2013). Detection Systems For Mass Spectrometry Imaging - A Perspective on Novel Developments with a Focus on Active Pixel Detectors. Rapid Commun. Mass Spectrom., 27(1), 1–23. doi:10.1002/rcm.6418