Fast modification of large gold nanoparticles with DNA is achieved by using DNA with a polycationic tail. The conjugated DNA is available for specific hybridization, and therefore can be used for DNA-based assays or for constructing nanoparticle superstructures based on DNA hybridization.

Chem. Commun.

Gill, R., Göeken, K., & Subramaniam, V. (2013). Fast, single-step, and surfactant-free oligonucleotide modification of gold nanoparticles using DNA with a positively charged tail. Chem. Commun., 49(97), 11400–11402. doi:10.1039/C3CC47138A