It is not understood how development occurs with astounding reproducibility despite variability on the cellular level. We show how a feedback mechanism involving cell signaling and migration generates an invariant cell fate pattern in C.elegans vulva development, even though anatomical variability causes strong initial variation in cell fate induction.

Additional Metadata
Publisher Elsevier/ Cell Press
Funder ERC , NWO
Persistent URL
Journal Cell Systems
Huelsz-Prince, G, & van Zon, J.S. (2017). Canalization of C. elegans Vulva Induction against Anatomical Variability. Cell Systems, 4, 219–230. doi:10.1016/j.cels.2017.01.009