Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual cells. This feature highlights recent developments in key analytical techniques suited for single-cell metabolic analysis with a special focus on mass spectrometry-based analytical platforms and RNA-seq, as well as imaging techniques that reveal stochasticity in metabolism.

The Netherlands Organisation for Scientific Research (NWO)
Anal. Chem.

Evers, T, Hochane, M, Tans, S.J, Heeren, R.M.A, Semrau, S, Nemes, P, & Mashaghi, A. (2019). Deciphering metabolic heterogeneity by single-cell analysis. Anal. Chem., 91(21), 13314–13323. doi:10.1021/acs.analchem.9b02410